Emotion Processing, Major Depression, and Functional Genetic Variation of Neuropeptide Y
نویسندگان
چکیده
منابع مشابه
Emotion Processing , Major Depression , and Functional Genetic Variation of Neuropeptide Y Brian
Context: Despite recent progress in describing the common neural circuitry of emotion and stress processing, the bases of individual variation are less well understood. Genetic variants that underlie psychiatric disease have proven particularly difficult to elucidate. Functional genetic variation of neuropeptide Y (NPY) was recently identified as a source of individual differences in emotion. L...
متن کاملEmotion processing, major depression, and functional genetic variation of neuropeptide Y.
CONTEXT Despite recent progress in describing the common neural circuitry of emotion and stress processing, the bases of individual variation are less well understood. Genetic variants that underlie psychiatric disease have proven particularly difficult to elucidate. Functional genetic variation of neuropeptide Y (NPY) was recently identified as a source of individual differences in emotion. Lo...
متن کاملAssociation of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression.
OBJECTIVE There is clear evidence of a genetic component in major depression, and several studies indicate that neuropeptide Y (NPY) could play an important role in the pathophysiology of the disease. A well-known polymorphism encoding the substitution of leucine to proline in the signal peptide sequence of NPY (Leu7Pro variation) was previously found to protect against depression. Our study ai...
متن کاملCerebrospinal Fluid Neuropeptide Y Levels in Major Depression and Reported Childhood Trauma
BACKGROUND Neuropeptide Y (NPY) may enhance resilience to chronic stress. Low brain NPY reported in major depression may normalize in response to antidepressants. METHODS In this study, we examined the relationship of reported childhood trauma to cerebrospinal fluid (CSF) NPY-like immunoreactivity (NPY-LI) in 61 medication-free major depressive disorder (MDD) patients and 20 matched healthy v...
متن کاملNeuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression.
Neuropeptide Y (NPY) has been found to play a role in the pathomechanism of both anxiety and depression. Thus, NPY is a promising candidate in the investigation of the clinical phenotype of "anxious depression". Five NPY gene variants were investigated for an influence on antidepressant treatment response in a sample of 256 patients with depression. Additionally, NPY gene impact on amygdala act...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Archives of General Psychiatry
سال: 2011
ISSN: 0003-990X
DOI: 10.1001/archgenpsychiatry.2010.197